Clark and Breslow staging. Find out what Clark and Breslow staging means for melanoma skin cancer. The stage of a melanoma describes how deeply it has grown into the skin, and whether it has spread. Doctors use 2 scales to describe how deeply the melanoma has gone into the skin.
New Melanoma Staging System â€“ By means of an unprecedented. the most accurate diagnosis and prognosis (a forecast of how the disease is likely to progress).. tissue more than 2 centimeters (1 cm equals 0.4 inch) from the primary tumor, but. metastatic sites) and elevated serum lactate dehydrogenase (LDH) level.
Clark level of invasion: A method for determining the prognosis (outlook) with melanoma.. Also called "melanoma in-situ." Level II: Penetration by melanomas into the second layer of the skin, the dermis. Levels III-IV: Melanomas invade deeper through the dermis, but are still contained completely within the skin.
NCI Dictionary of Cancer Terms. Skin cancer that has spread from the epidermis (outer layer of skin) down into the papillary dermis (the thin top layer of the dermis). Clark levels of skin cancer. In Clark Level I, the cancer is in the epidermis only.
2005;17(2):119-131. 0Read. The thinner the melanoma, the better the prognosis.. If the melanoma has penetrated to the lower dermis (Clark level IV).
Clark's level is a staging system, used in conjunction with Breslow's depth, which describes the level of anatomical invasion of the melanoma in the skin. Level 1 : Melanoma confined to the epidermis (melanoma in situ); Level 2 : Invasion into. how Breslow Thickness relates to prognosis and survival time in melanoma.
Clark level III refers to melanomas that fill and/or expand the papillary dermis (Fig