HER2-targeted therapies can be used to treat HER2–positive metastatic breast cancer.. So, HER2–positive metastatic breast cancer that has spread to the brain is often treated with surgery and/or radiation therapy (see below). Trastuzumab (Herceptin, Ogivri).
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Each drug can be used in combination with hormone therapy to treat hormone receptor-positive, HER2-negative metastatic breast cancers. Abemaciclib may also be used alone to treat these cancers. Other CDK4/6 inhibitors are under study for use in metastatic breast cancer treatment.
In HER2–positive (HER2+) breast cancer, cancer cells have more HER2 receptors than normal cells. Metastatic breast cancer is breast cancer that has spread .
Correspondence from The New England Journal of Medicine â€” Treatment of HER2–Positive Metastatic Breast Cancer.