More than 60% of all Stage IV melanoma patients will develop brain metastases at some point but certain factors can increase that risk: The primary tumor was on the head, neck, trunk, or abdomen. The primary tumor was ulcerated or deep or invasive. The melanoma was unresectable Stage III or Stage IV when diagnosed.
Compared with primary lung, breast, renal or colorectal cancer, melanoma has the highest propensity to metastasize to the brain: over one-third of patients with metastatic melanoma will eventually develop a clinically apparent brain metastasis Autopsy reports indicate that the incidence of brain metastases may be as.
In a melanoma-specific brain metastasis graded prognostic assessment, KPS. that range from 0 to 4, correlating with median survival in months (Table 2).. . In a phase III trial, BRAF-mutant patients with metastatic or unresectable stage IIIc .