Genes are inherited from each parent. They determine various physical features and may predispose people to certain diseases. All cancers, but especially colon and rectal cancers, commonly referred to as colorectal cancer (CRC), have hereditary factors that potentially increase one's risk.
Between 2% to 5% of all colon cancers arise in the setting of well defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and certain hamartomatous polyposis conditions. Each is associated with a high risk of colon cancer.
Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC
Inherited colorectal cancers are less common (about 5%) and occur when gene mutations, or changes, are passed within a family from 1 generation to the next .