Most cases of breast cancer are not caused by inherited genetic factors. These cancers are associated with somatic mutations in breast cells that are acquired during a person's lifetime, and they do not cluster in families. In hereditary breast cancer, the way that cancer risk is inherited depends on the gene involved.
Most inherited cases of breast cancer are associated with mutations in two genes: BRCA1 (BReast CAncer gene one) and BRCA2 (BReast CAncer gene two).. Women who are diagnosed with breast cancer and have a BRCA1 or BRCA2 mutation often have a family history of breast cancer, ovarian cancer, and other cancers.
Learn more about breast cancer in families (hereditary breast cancer), genes, including BRCA, and risk factors in relation to being diagnosed with breast cancer.
Everyone has these genes, but some people have an inherited mutation in one or both that increases the risk of breast cancer. In addition to mutations in BRCA1
It is uncertain how much a woman's risk of breast cancer is increased when a man in the family has breast cancer, unless this is due to an inherited mutation.
A diagnosis of Hereditary Breast and Ovarian Cancer Syndrome (HBOC) is considered when there are multiple cases of breast cancer and/or ovarian cancer on .
For women with a hereditary risk of breast cancer, the Johns Hopkins Breast Center in Baltimore, MD, offers guidance on genetic testing, screenings and .
How much does having a BRCA1 or BRCA2 gene mutation increase a woman's risk of breast and ovarian cancer? What other cancers have been linked to .