Find out what Clark and Breslow staging means for melanoma skin cancer.. The number stages look at the melanoma depth, and also whether the melanoma has. Level 4 means the melanoma has spread into the reticular or deep dermis.
Skin cancer that has spread down into the reticular dermis (the thick bottom layer of the dermis).
Therefore, the physician may consider using a more aggressive treatment than would. By the time a melanoma advances to Stage III or beyond, an important .
Another system describes the thickness of a melanoma in relation to its penetration into the skin instead of actually measuring it. The Clark level of a melanoma .
Clark level of invasion: A method for determining the prognosis (outlook) with melanoma.. Also called "melanoma in-situ." Level II: Penetration by melanomas into the second layer of the skin, the dermis. Levels III-IV: Melanomas invade deeper through the dermis, but are still contained completely within the skin.
Clark level III refers to melanomas that fill and/or expand the papillary dermis (Fig .. 4. invasion into the reticular dermis. 5. invasion into subcutaneous fat.. are regarded as being 'thin melanomas' and generally have an excellent prognosis.