As the name implies, it manifests without other signs or symptoms of an underlying autoimmune disorder. Neutropenia can be moderate to severe and complicated by serious infections.. Secondary autoimmune neutropenia is seen primarily in adults and usually occurs within the context of systemic autoimmune disease.
The normal ANC for Caucasians (adults and children over two) is anything above. The ANC for a child with benign neutropenia may be below 500, but when .
Children with chronic benign neutropenia have mild infections, and their bone marrow is able to produce enough neutrophils to respond to an infection. However, when the ANC is low (and especially when it is severely low <0.5 x109/L), the body has difficulty fighting bacterial infections.
Primary AIN among adults is extremely rare, and only a few cases have been. .. Successful treatment of chronic autoimmune neutropenia with cyclosporin A.
(Dale, unpublished data) In children, acute neutropenia with viral infections is commonly observed and chronic autoimmune neutropenia is also a relatively .